Bridging the gap with our small-animal radiation research platform

In this paper we tried to mimic the standard-of-care for the treatment of glioblastoma in patients using an animal model. For radiation treatment, three non-coplanar arcs were used to deliver a high dose to the tumor and a minimal dose to the surrounding healthy tissue, using a preclinical radiation research platform. Our approach was a major step forward in bridging the gap between preclinical and clinical radiation research.

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Bolcaen, Julie, Benedicte Descamps, Karel Deblaere, Tom Boterberg, Giorgio Hallaert, Caroline Van den Broecke, Elke Decrock, Anne Vral, Luc Leybaert, Christian Vanhove, and Ingeborg Goethals. 2014. “MRI-Guided 3D Conformal Arc Micro-Irradiation of a F98 Glioblastoma Rat Model Using the Small Animal Radiation Research Platform (SARRP).” JOURNAL OF NEURO-ONCOLOGY 120 (2): 257–266.

http://doi.org/10.1007/s11060-014-1552-9