Biomarkers for Huntington's disease

• Altered cortico-striatal FC in SuCN - LCN regions in the 12-month-old zQ175DN mice

• Reduced FC in DMLN and ACN regions at 6- and 10-month-old zQ175DN mice

• Normal aging inverted U-shape evolution of connectivity is disrupted

Resting-state fMRI reveals longitudinal alterations in brain network connectivity in the zQ175DN mouse model of Huntington’s disease

Vasilkovska Tamara, Adhikari Mohit, van Audekerke Johan, Salajeghe Somaie, Pustina Dorian, Cachope Roger, Tang Haiying, Liu Longbin, Munoz-Sanjuan Ignacio, Van Der Linden Anne-Marie, Verhoye Marleen. Neurobiology of disease - ISSN 1095-953X - 181(2023), 106095