INTERACTIONS

Flanders BioImaging aims to intergrate multi-modal imaging expertise across the microscopy, preclinical and clinical domains between institutions. Major interactions/existing joint projects between sites in the areas indicated are indicated below for each domain.

FBI_Interactions.jpg

EM Histology and SPIM

Neuronal imaging

Label free (SHG)

Multiphoton

High Content Imaging

Molecular fluctuations and dynamics (FCS, FRAP, RICS)

Image reconstruction/processing

Small animal PET/CT/MR/SPECT

Optical imaging

Image reconstruction/processing

Human PET/CT/MR/PET-MR

Examples of recent studies carried out within FBI are shown below:

Collaborations.PNG

A: live second harmonic imaging of striated muscle myosin (magenta) and multiphoton GCaMP (green) in mouse esophageal wall (KUL); B: human dental pulp stem cells in tethered collagen type I hydrogels (cells in red by autofluorescence and collagen fibrils in green by second harmonic generation) (UH); C: Whole brain depth-color coded imaging of vasculature in the cleared mouse brain (UA); D: Confocal imaging of human lung fibroblasts plus carbonaceous particles by non-descanned twophoton imaging. (UH); E: 3D BLI of lung metastases with anatomical CT atlas overlay (KUL); F: microPET-MR of Zr89-labeled novel antibody tumor tracer (KUL); G: Spectral unmixing of GFP-expressing tumors and tissue autofluorescence (KUL); H: Atherosclerotic plaque imaging by 18F-cAbVCAM1-5 in ApoE-/- mice (VUB) I: 18F-MK6240 tau worldwide first-inman study in Alzheimer’s disease patient (KUL/Merck); J: SSR2 imaging of suicide reporter gene for pluripotent stem cell-derived therapy of myocardial infarction (KUL); K: MR tractography of the arcuate fasciculus for brain tumor surgery (KUL); L: Selective dopamine transporter PETMR (18F-PE2I) (KUL); M: Fibrous dysplasia mimicking small bone metastasis on 68Ga-PSMA PET/MRI (KUL)